Article
Mitochondrial Fragmentation Promotes Inflammation Resolution Responses in Macrophages via Histone Lactylation.
Molecular and cellular biology - 1 Jan 2023
Susser Leah I, Nguyen My-Anh, Geoffrion Michele, Emerton Christina, Ouimet Mireille, Khacho Mireille, Rayner Katey J
Abstract excerpt
During the inflammatory response, macrophage phenotypes can be broadly classified as pro-inflammatory/classically activated "M1", or pro-resolving/alternatively "M2" macrophages. Although the classification of macrophages is general and assumes there are distinct phenotypes, in reality macrophages exist across a spectrum and must transform from a pro-inflammatory state to a proresolving state following an...
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