Article
Macrophage activation as an archetype of mitochondrial repurposing.
Molecular aspects of medicine - 1 Feb 2020
Jones Anthony E, Divakaruni Ajit S
Abstract excerpt
Mitochondria are metabolic organelles essential not only for energy transduction, but also a range of other functions such as biosynthesis, ion and metal homeostasis, maintenance of redox balance, and cell signaling. A hallmark example of how mitochondria can rebalance these processes to adjust cell function is observed in macrophages. These innate immune cells are responsible for a remarkable breadth of...
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