FACT subunit SUPT16H associates with BRD4 and contributes to silencing of antiviral interferon signaling

Abstract excerpt

<h4>Summary/Abstract</h4> FACT ( FA cilitates C hromatin T ranscription) is a heterodimeric protein complex composed of SUPT16H and SSRP1, and a histone chaperone participating in chromatin remodeling during gene transcription. FACT complex is profoundly regulated, and contributes to both gene activation and suppression. Here we reported that SUPT16H, a subunit of FACT, is acetylated at lysine 674 (K674) of mi...

Topics

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• Cytokine Signaling Pathways and Interactions
• DNA Repair Mechanisms
• Epigenetics and DNA Methylation
• Genomics and Chromatin Dynamics
• Immune Cell Function and Interaction
• interferon and immune responses
• Protein Degradation and Inhibitors
• RNA regulation and disease

Identifiers and source

Literature Corpus work

82a2a586-7666-543f-a9b9-be24e37b0f22

DOI

10.1101/2021.04.21.440833