Article

A FACT-ETS-1 Antiviral Response Pathway Restricts Viral Replication and is Countered by Poxvirus A51R Proteins

2023-02-08

Abstract excerpt

The FACT complex is an ancient chromatin remodeling factor comprised of Spt16 and SSRP1 subunits that regulates specific eukaryotic gene expression programs. However, whether FACT regulates host immune responses to infection was unclear. Here, we identify an antiviral pathway mediated by FACT, distinct from the interferon response, that restricts poxvirus replication. We show that early viral gene expression trigg...

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Literature Corpus work: 291abec5-f3ab-5601-9ab4-ffcb28dd702b
DOI: 10.1101/2023.02.08.527673

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A FACT-ETS-1 Antiviral Response Pathway Restricts Viral Replication and is Countered by Poxvirus A51R ProteinsDOI 10.1101/2023.02.08.527673Read

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