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Histone chaperone FACT regulates homologous recombination by chromatin remodeling through interaction with RNF20

1 Jan 2013

Abstract excerpt

The E3 ubiquitin ligase RNF20 regulates chromatin structure through ubiquitylation of histone H2B, so that early homologous recombination repair (HRR) proteins can access the DNA in eukaryotes during repair. However, it remains unresolved how RNF20 itself approaches the DNA in the presence of chromatin structure. Here, we identified the histone chaperone FACT as a key protein in the early steps of HRR. Depletion...

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PMID: 24357716
DOI: 10.1242/jcs.135855

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Histone chaperone FACT regulates homologous recombination by chromatin remodeling through interaction with RNF20PMID 24357716Read ↗

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