Building an optimal predictive model for imputing tissue-specific gene expression by combining genotype and whole-blood transcriptome data.

Abstract excerpt

Accurate imputation of tissue-specific gene expression can be a powerful tool for understanding the biological mechanisms underlying human complex traits. Existing imputation methods can be grouped into two categories according to the types of predictors used. The first category uses genotype data, while the second category uses whole-blood expression data. Both data types can be easily collected from blood,...

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