TransferTWAS: A transfer learning framework for cross-tissue transcriptome-wide association study.

Abstract excerpt

Transcriptome-wide association studies (TWASs) utilize gene-expression data to explore the genetic basis of complex traits. A key challenge in TWASs is developing robust imputation models for tissues with limited sample sizes. This paper introduces transfer learning-assisted TWAS (TransferTWAS), a framework that adaptively transfers information from multiple tissues to improve gene-expression prediction in the...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cholesterol, LDL
• Share to Computer Simulation