Article

ACE inhibition increases Alzheimer’s disease risk by promoting tau phosphorylation

2025-08-12

Abstract excerpt

Reportedly, over 60% of individuals in the USA aged 65 or older take antihypertensive medications, making it crucial to evaluate their potential impact on dementia. Alzheimer’s disease (AD), the most prevalent form of dementia, develops insidiously over decades, effectively precluding clinical trials of antihypertensive drug effects on AD risk. Through a triangulation approach integrating large-scale human genetic...

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Literature Corpus work: 33de54ee-8264-5c45-9ec9-3644f59c9ff1
DOI: 10.1101/2025.08.11.25333412

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