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Article

Pathways underlying selective neuronal vulnerability in Alzheimer's disease: Contrasting the vulnerable locus coeruleus to the resilient substantia nigra

1 Mar 2025

Abstract excerpt

INTRODUCTION: Alzheimer's disease (AD) selectively affects certain brain regions, yet the mechanisms of selective vulnerability remain poorly understood. The neuromodulatory subcortical system, which includes nuclei exhibiting a range of vulnerability and resilience to AD-type degeneration, presents a framework for uncovering these mechanisms. METHODS: We leveraged transcriptomics and immunohistochemistry in...

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PMID: 40135662
DOI: 10.1002/alz.70087

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