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Locus coeruleus vulnerability to tau hyperphosphorylation in a rat model

9 Nov 2024

Abstract excerpt

Post-mortem investigations indicate that the locus coeruleus (LC) is the initial site of hyperphosphorylated pretangle tau, a precursor to neurofibrillary tangles (NFTs) found in Alzheimer's disease (AD). The presence of pretangle tau and NFTs correlates with AD progression and symptomatology. LC neuron integrity and quantity are linked to cognitive performance, with degeneration strongly associated with AD....

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PMID: 39520141
DOI: 10.1111/acel.14405

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