Article

The non-essentiality of essential genes suggests a loss-of-function therapeutic strategy for loss-of-function human diseases

2016-02-22

Abstract excerpt

Essential genes refer to those whose null mutation leads to lethality or sterility. We propose that the fatal effect of inactivating an essential gene can be attributed to either the loss of indispensable core cellular function (type I), or the gain of fatal side effects after losing dispensable periphery function (type II). In principle, inactivation of the type I essential genes can be rescued only by regain of...

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Identifiers and source

Literature Corpus work: 82865083-3267-51f4-be85-d05e558f6f83
DOI: 10.1101/040568

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