Article

Chemoproteomics identifies proteoform-selective caspase-2 inhibitors

2023-10-26

Abstract excerpt

<h4>ABSTRACT</h4> Caspases are a highly conserved family of cysteine-aspartyl proteases known for their essential roles in regulating apoptosis, inflammation, cell differentiation, and proliferation. Complementary to genetic approaches, small-molecule probes have emerged as useful tools for modulating caspase activity. However, due to the high sequence and structure homology of all twelve human caspases, achievin...

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Literature Corpus work: 8be8c08a-fb4f-5a8f-a0fd-ffc56d277db9
DOI: 10.1101/2023.10.25.563785

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