Article

DCAF16-Based Covalent Degradative Handles for the Modular Design of Degraders

2025-04-25

Abstract excerpt

Targeted protein degradation (TPD) is a powerful strategy for targeting and eliminating disease-causing proteins. While heterobifunctional Proteolysis-Targeting Chimeras (PROTACs) are more modular, the rational design of monovalent or molecular glue degraders remains challenging. In this study, we generated a small library of BET-domain inhibitor JQ1 analogs bearing elaborated electrophilic handles to identify per...

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Literature Corpus work: a8627877-0a2a-5cb3-8a4a-c0a67b37468c
DOI: 10.1101/2025.04.25.650514

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