Article

Correction of the cytosine deamination artifacts in FFPE-based sequencing experiments

2026-08-16

Abstract excerpt

<h4>ABSTRACT</h4> Formalin-fixed, paraffin-embedded (FFPE) tissues remain an essential resource for molecular studies, yet formalin-induced cytosine deamination introduces characteristic C>T/G>A artifacts that compromise the accuracy of next-generation sequencing (NGS) analyses. Numerous computational methods and enzymatic DNA repair strategies have been proposed to reduce these artifacts, but no systematic compa...

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Literature Corpus work: fb0c9f70-f60d-5073-80bc-b96da660cfe6
DOI: 10.64898/2026.08.11.744151

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