Article

MICAL1 activation by PAK1 mediates actin filament disassembly

2021-09-16

Abstract excerpt

<h4>Summary</h4> The MICAL1 monooxygenase has emerged as an important regulator of filamentous actin (F-actin) structures that contribute to numerous processes including nervous system development, cell morphology, motility, viability and cytokinesis [1–4]. Activating MICAL1 mutations have been linked with autosomal-dominant lateral temporal epilepsy, a genetic syndrome characterized by focal seizures with audit...

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Literature Corpus work: 823f88f6-eaeb-5b57-a0cc-54ee6285efb8
DOI: 10.1101/2021.09.15.460490

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