Article

A complex of MAST1 and 14-3-3η regulates Tau phosphorylation in the developing cortex

2025-07-11

Abstract excerpt

The MAST family of serine/threonine kinases has been implicated in a spectrum of human neurodevelopmental disorders. However, little is known about their biological function or regulation. Seeking to fill these gaps in our knowledge, we have identified upstream and downstream partners of MAST1. 14-3-3η, a neuronal 14-3-3 paralog, specifically interacts with MAST1 at two regulatory serines, S90 and S161. PAK, a neu...

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Literature Corpus work: 24d707ce-934c-5f9b-a357-e772588404a5
DOI: 10.1101/2025.07.09.663707

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