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Article

The p21-activated kinases in neural cytoskeletal remodeling and related neurological disorders

11 Dec 2020

Abstract excerpt

The serine/threonine p21-activated kinases (PAKs), as main effectors of the Rho GTPases Cdc42 and Rac, represent a group of important molecular switches linking the complex cytoskeletal networks to broad neural activity. PAKs show wide expression in the brain, but they differ in specific cell types, brain regions, and developmental stages. PAKs play an essential and differential role in controlling neural...

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PMID: 33306168
DOI: 10.1007/s13238-020-00812-9

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