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Article

Serine 518 phosphorylation modulates merlin intramolecular association and binding to critical effectors important for NF2 growth suppression.

Oncogene - 4 Nov 2004

Rong Rong, Surace Ezequiel I, Haipek Carrie A, Gutmann David H, Ye Keqiang

Abstract excerpt

The neurofibromatosis 2 (NF2) tumor suppressor protein, merlin, functions as a negative growth regulator; however, the molecular mechanisms that underlie merlin regulation remain elusive. Recent studies have implicated merlin phosphorylation in regulating merlin subcellular localization and growth suppression. P21-activated kinase (PAK), a downstream target of Rac1/Cdc42, directly phosphorylates merlin at Serine...

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Source

Identifiers

PMID: 15378014
DOI: 10.1038/sj.onc.1207794

Genes

PAK2
NF2
CD44

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Serine 518 phosphorylation modulates merlin intramolecular association and binding to critical effectors important for NF2 growth suppression.PMID 15378014Read ↗

p21-activated Kinase Links Rac/Cdc42 Signaling to MerlinSemantic proximity Read ↗

Merlin phosphorylation by p21-activated kinase 2 and effects of phosphorylation on merlin localization.Semantic proximity Read ↗

Distinct overlapping sequences at the carboxy-terminus of merlin regulate its tumour suppressor and morphogenic activity.Semantic proximity Read ↗

Akt phosphorylation regulates the tumour-suppressor merlin through ubiquitination and degradation.Semantic proximity Read ↗

Conformational flexibility determines the Nf2/merlin tumor suppressor functionsSemantic proximity Read ↗

Protein 4.1 tumor suppressors: getting a FERM grip on growth regulationSemantic proximity Read ↗

The Neurofibromatosis 2 Protein, Merlin, Regulates Glial Cell Growth in an ErbB2- and Src-Dependent MannerSemantic proximity Read ↗

Effect of merlin phosphorylation on neurofibromatosis 2 (NF2) gene function.Semantic proximity Read ↗

Shedding light on Merlin's wizardry.Semantic proximity Read ↗

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