Article

MICAL1 Contributes to Myogenic Differentiation by Modulating Actin Remodeling and YAP1 Nuclear Localization in C2C12 Myoblasts

2026-07-16

Abstract excerpt

Molecule Interacting with CasL 1 (MICAL1) is a flavoprotein monooxygenase that depolymerizes filamentous actin (F-actin) through methionine oxidation. Transcriptomic studies have linked MICAL1 downregulation to skeletal muscle atrophy and muscular dystrophy, yet its functional contribution to myogenesis remains unexplored. We found that MICAL1 protein increased progressively during myogenic differentiation of C2C1...

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Literature Corpus work: a216a0bd-5cdf-52e8-b80e-85710037bfd9
DOI: 10.20944/preprints202607.1205.v1

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