Article

Synaptic activity controls local exposure of an ‘eat-me’ signal via ANO3-ITPR1 signaling

2026-06-30

Abstract excerpt

Neuronal synapses are eliminated during brain development and disease through pruning by glial cells. Individual synapses are marked for engulfment by ‘eat-me’ signals, which include externalized phosphatidylserine. In apoptotic cells, phosphatidylserine externalization is driven by caspase-dependent activation of Xkr scramblases 1 and inactivation of specific flippases 2 . Localized caspase activation at neuron...

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Literature Corpus work: 9aef2922-1d60-588b-854d-c77c169d9dda
DOI: 10.64898/2026.06.26.734915

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