Article

Evolution of mechanical chromatin insulators from selfish genetic elements

2026-08-10

Abstract excerpt

Genomes require physical boundaries to separate active and repressed chromatin, a function traditionally attributed to insulator proteins. Here, we show that genomic insulation can also emerge from physical properties encoded directly within the DNA polymer. In C. elegans , transcription-coupled mutational bias remodels Helitron transposon minisatellites to match the DNA helical repeat. The resulting 10-bp period...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 822fdbd9-8e8f-5f16-ab98-c1a2404c03de
DOI: 10.64898/2026.08.08.743475

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Evolution of mechanical chromatin insulators from selfish genetic elementsDOI 10.64898/2026.08.08.743475Read

Periodic stiffness encoded in genomes governs DNA mechanicsSemantic proximity Read

Clustered transposon insertion via formation of chromatin loopsSemantic proximity Read

Cohesin forms fountains at active enhancers in <i>C. elegans</i>Semantic proximity Read

CpG islands act as topological sinks for transcription-induced DNA supercoilingSemantic proximity Read

Widespread transposon co-option in the <i>Caenorhabditis</i> germline regulatory networkSemantic proximity Read

Distinct principles of genome compartmentalization in <i>Drosophila</i> and humans revealed by osmotic stressSemantic proximity Read

Natural Variation in the Distribution and Abundance of Transposable Elements Across the Caenorhabditis elegans Species.Semantic proximity Read

Loops are Geometric Catalysts for DNA IntegrationSemantic proximity Read

Multiscale chromatin modeling of chromosome X structural changes upon inactivation highlights the differential regulatory mechanism of <i>Xist</i>Semantic proximity Read

Thermosensory neurons control genetic inheritance through regulation of germline transposonsSemantic proximity Read

Mechanotransduction via the LINC complex regulates DNA replication in myonuclei.Semantic proximity Read

Loop Extrusion Accelerates Long-Range Enhancer-Promoter Searches in Living EmbryosSemantic proximity Read