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Article

Mechanotransduction via the LINC complex regulates DNA replication in myonuclei.

The Journal of cell biology - 4 Jun 2018

Wang Shuoshuo, Stoops Elizabeth, Cp Unnikannan, Markus Barak, Reuveny Adriana, Ordan Elly, Volk Talila

Abstract excerpt

Nuclear mechanotransduction has been implicated in the control of chromatin organization; however, its impact on functional contractile myofibers is unclear. We found that deleting components of the linker of nucleoskeleton and cytoskeleton (LINC) complex in Drosophila melanogaster larval muscles abolishes the controlled and synchronized DNA endoreplication, typical of nuclei across myofibers, resulting in...

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Source

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Identifiers

PMID: 29650775
DOI: 10.1083/jcb.201708137
PMCID: PMC5987719

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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