Back to search

Article

Integrated analysis of single-cell RNA sequencing and bulk RNA sequencing reveals T-cell-associated prognostic risk models and the regulation of the tumour immune microenvironment in colorectal cancer

2026-08-31

Abstract excerpt

<title>Abstract</title> <p> <bold>Objective:</bold> Colorectal cancer (CRC), a highly prevalent gastrointestinal malignancy, has experienced a paradigm shift in therapeutic strategies driven by recent advances in immunotherapy. Nevertheless, the precise impact of T-cell subpopulation heterogeneity and functional evolution within the tumor microenvironment (TME) on clinical prognosis warrants further elucidation...

Identifiers and source

Literature Corpus work
8228a153-af9c-54d3-8924-577e89655974
DOI
10.21203/rs.3.rs-10717563/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Integrated analysis of single-cell RNA sequencing and bulk RNA sequencing reveals T-cell-associated prognostic risk models and the regulation of the tumour immune microenvironment in colorectal cancerDOI 10.21203/rs.3.rs-10717563/v1
Integrated single-cell and bulk RNA-seq for constructing a prognostic risk model of immune-related genes in colorectal cancerSemantic proximity
Integrated single-cell and bulk RNA-seq analysis reveals a novel T-cell signature for prognosis and treatment response in colorectal cancerSemantic proximity
Identification of a novel T cell-related signature to predict prognosis in colorectal cancer via integrating single-cell and bulk RNA sequencingSemantic proximity
Establishing and validating a prognostic model for colorectal cancer patients by integrating data from single-cell RNA sequencing and bulk RNA sequencingSemantic proximity
Integrated Single‐Cell RNA ‐Seq Reveals Immunosuppressive Mechanisms of Treg Cell Differentiation and Tumor Microenvironment Interactions in Colorectal CancerSemantic proximity
The functional and phenotypic diversity of single T-cell infiltrates in human colorectal cancer as correlated with clinical outcomeSemantic proximity
A Mutational Signature that Predicts Prognosis and Benefit of Immune Checkpoint Blockade in Colorectal CancerSemantic proximity
An immune landscape based prognostic signature predicts the immune status and immunotherapeutic responses of patients with colorectal cancer.Semantic proximity
Multiregion single‐cell sequencing reveals the transcriptional landscape of the immune microenvironment of colorectal cancerSemantic proximity
Single-cell technology reveals the crosstalk between tumor cells and immune cells: driving immune signal transduction and inflammation-mediated cardiac dysfunction in the tumor microenvironment of colorectal cancerSemantic proximity
Single-Cell Transcriptomic Profiling Reveals T-Cell Functional Shifts in Primary Versus Metastatic Colorectal CancerSemantic proximity
T-Cell Infiltration and Clonality May Identify Distinct Survival Groups in Colorectal Cancer: Development and Validation of a Prognostic Model Based on The Cancer Genome Atlas (TCGA) and Clinical Proteomic Tumor Analysis Consortium (CPTAC)Semantic proximity
Select a neighboring publication to make it the new centre.