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An immune landscape based prognostic signature predicts the immune status and immunotherapeutic responses of patients with colorectal cancer.

Life sciences - 15 Nov 2020

Li Mengting, Li Wenjie, Yang Xueying, Wang Haizhou, Peng Yanan, Yin Jinwen, Lu Yuanyuan, Liu Lan, Shang Jian, Zhao Qiu

Abstract excerpt

AIMS: Colorectal cancer (CRC) is one of the most common cancers with poor prognosis worldwide. The advent of immunotherapy has greatly improved survival in refractory patients of CRC. In this study, we aimed to identify reliable immune classification and biomarkers that predict immunotherapeutic responses in CRC patients. MATERIALS AND METHODS: Based on transcriptome profiles of two publicly available CRC...

Topics

Colorectal Neoplasms
Female
Humans
Immunotherapy
Kaplan-Meier Estimate
Male
Middle Aged
Phenotype
Predictive Value of Tests
Prognosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32888940
DOI: 10.1016/j.lfs.2020.118368

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