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Single-Cell Transcriptomic Profiling Reveals T-Cell Functional Shifts in Primary Versus Metastatic Colorectal Cancer

2026-04-15

Abstract excerpt

<title>Abstract</title> <p>Colorectal cancer (CRC) develops in the colon or rectum and is the second leading cause of cancer-related mortalities, with high rates of liver metastasis (LM). The tumor immune microenvironment (TIME) of primary CRC and LM-CRC is immunosuppressive, leading to T-cell dysfunction. Hence, this study employed computational techniques to unravel the novel T-cell-specific biomarkers being dy...

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Literature Corpus work
0e4570ca-e3c8-55d3-91da-8d1defb23b67
DOI
10.21203/rs.3.rs-9411430/v1
Open publication

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Single-Cell Transcriptomic Profiling Reveals T-Cell Functional Shifts in Primary Versus Metastatic Colorectal CancerDOI 10.21203/rs.3.rs-9411430/v1
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