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A Mutational Signature that Predicts Prognosis and Benefit of Immune Checkpoint Blockade in Colorectal Cancer

2020-12-11

Abstract excerpt

<h4>Background: </h4> Colorectal cancer (CRC) is characterized by broad genomic and transcriptional heterogeneity. However, the genomic basis of this variability remains poorly understood. Our pilot study identified mutated genes were associated with immune infiltration. This study aims to explore a novel mutational signature (MS) in tumor microenvironment (TME) of CRC. <h4>Methods: </h4>: We integrated single nuc...

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Literature Corpus work
fae9833d-1a73-5319-a210-5f4245e1c9e9
DOI
10.21203/rs.3.rs-122186/v1
Open publication

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A Mutational Signature that Predicts Prognosis and Benefit of Immune Checkpoint Blockade in Colorectal CancerDOI 10.21203/rs.3.rs-122186/v1
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