Article

Identifying Cancer-Relevant Mutations in the DLC START Domain using Evolutionary and Structure-Function Analyses

2020-09-20

Abstract excerpt

Rho GTPase signaling promotes proliferation, invasion, and metastasis in a broad spectrum of cancers. Rho GTPase activity is regulated by the Deleted in Liver Cancer (DLC) family of bonafide tumor suppressors which directly inactivate Rho GTPases by stimulating GTP hydrolysis. In addition to a RhoGAP domain, DLC proteins contain a StAR-related lipid transfer (START) domain. START domains in other organisms bind hy...

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Literature Corpus work: 822336d7-85f4-57f4-9df0-8ed6bfacb55f
DOI: 10.1101/2020.09.20.305201

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