Article
Characterization of cancer-driving nucleotides (CDNs) across genes, cancer types, and patients.
eLife - 17 Dec 2024
Zhang Lingjie, Deng Tong, Liufu Zhongqi, Chen Xiangnyu, Wu Shijie, Liu Xueyu, Shi Changhao, Chen Bingjie, Hu Zheng, Cai Qichun, Liu Chenli, Li Mengfeng, Tracy Miles E, Lu Xuemei, Wu Chung-I, Wen Hai-Jun
Abstract excerpt
A central goal of cancer genomics is to identify, in each patient, all the cancer-driving mutations. Among them, point mutations are referred to as cancer-driving nucleotides (CDNs), which recur in cancers. The companion study shows that the probability of i recurrent hits in n patients would decrease exponentially with i; hence, any mutation with i ≥ 3 hits in The Cancer Genome Atlas (TCGA) database is a...
Topics
- Humans
- Neoplasms
- Nucleotides
- Point Mutation
- Genomics
- Mutation