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Article

Deleted in liver cancer protein family in human malignancies (Review)

5 Jul 2011

Abstract excerpt

The Deleted in Liver Cancer (DLC) protein family comprises proteins that exert their function mainly by the Rho GTPase-activating protein (GAP) domain and by regulation of the small GTPases. Since Rho GTPases are key factors in cell proliferation, polarity, cytoskeletal remodeling and migration, the aberrant function of their regulators may lead to cell transformation. One subgroup of these proteins is the DLC...

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PMID: 22866123
DOI: 10.3892/ol.2011.345

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Deleted in liver cancer protein family in human malignancies (Review)PMID 22866123Read ↗

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Deleted in Liver Cancer (DLC) 2 Encodes a RhoGAP Protein with Growth Suppressor Function and Is Underexpressed in Hepatocellular CarcinomaSemantic proximity Read ↗

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Deleted in liver cancer 1 (DLC1) utilizes a novel binding site for Tensin2 PTB domain interaction and is required for tumor-suppressive function.Semantic proximity Read ↗

Deleted in Liver Cancer 2 (DLC2) Was Dispensable for Development and Its Deficiency Did Not Aggravate HepatocarcinogenesisSemantic proximity Read ↗

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