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Article

The tumor suppressor activity of DLC1 requires the interaction of its START domain with Phosphatidylserine, PLCD1, and Caveolin-1.

Molecular cancer - 2 Nov 2021

Sanchez-Solana Beatriz, Wang Dunrui, Qian Xiaolan, Velayoudame Parthibane, Simanshu Dhirendra K, Acharya Jairaj K, Lowy Douglas R

Abstract excerpt

BACKGROUND: DLC1, a tumor suppressor gene that is downregulated in many cancer types by genetic and nongenetic mechanisms, encodes a protein whose RhoGAP and scaffolding activities contribute to its tumor suppressor functions. The role of the DLC1 START (StAR-related lipid transfer; DLC1-START) domain, other than its binding to Caveolin-1, is poorly understood. In other START domains, a key function is that they...

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Identifiers

PMID: 34727930
DOI: 10.1186/s12943-021-01439-y
PMCID: PMC8561924

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