Article

SUSD4 Controls Activity-Dependent Degradation of AMPA Receptor GLUA2 and Synaptic Plasticity

2019-11-29

Abstract excerpt

<h4>Summary</h4> At excitatory synapses, the choice between recycling or degradation of glutamate AMPA receptors controls the direction of synaptic plasticity. In this context, how the degradation machinery is targeted to specific synaptic substrates in an activity-dependent manner is not understood. Here we show that SUSD4, a complement-related transmembrane protein, is a tether for HECT ubiquitin ligases of the...

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Literature Corpus work: 821b82b8-ccd1-5d60-be89-35b9048d35ac
DOI: 10.1101/859587

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