Article

Physiological and pathophysiological homeostasis of astroglial channel proteins by Nedd4-2

2019-07-04

Abstract excerpt

<h4>ABSTRACT</h4> Nedd4-2 is an E3 ubiquitin ligase, missense mutation of which is related to familial epilepsy, indicating its critical role in regulating neuronal network activity. However, Nedd4-2 substrates involved in neuronal network function have yet to be identified. Using mouse lines lacking Nedd4-1 and Nedd4-2, we identified astrocytic channel proteins inwardly rectifying K + channel 4.1 (Kir4.1) and C...

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Literature Corpus work: 35c5c0b4-991d-5d6d-b9e1-76d6be83e27b
DOI: 10.1101/683441

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