Article

Angelman Syndrome causing UBE3A ligase displays predominantly synaptic ubiquitination activity in the mouse brain

2023-03-21

Abstract excerpt

<title>Abstract</title> <p>Angelman Syndrome (AS) is a neurodevelopmental disorder with complex symptomatology caused by the loss of maternal allele expression of one single gene in the brain, the ubiquitin E3 ligase <italic>UBE3A</italic>. The underlying genetic basis of AS, and the phenotypes observed in both humans and in animal models of AS, have previously been extensively described. However, the molecular m...

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Literature Corpus work: ff145ffb-228b-5963-9204-a6a28f398207
DOI: 10.21203/rs.3.rs-2665803/v1

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