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Article

Cullin-RING Ubiquitin Ligases in Neurodevelopment and Neurodevelopmental Disorders

2025-03-07

Abstract excerpt

Ubiquitination is dynamic and tightly regulated post-translational modifications essential for modulating protein stability, trafficking, and function to preserve cellular homeostasis. This process is orchestrated through a hierarchical enzymatic cascade involving three key enzymes: the E1 ubiquitin-activating enzyme, the E2 ubiquitin-conjugating enzyme, and the E3 ubiquitin ligase. The final step of ubiquitinatio...

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Literature Corpus work
b371876a-75e5-5f3a-a51f-06ca8c7465e4
DOI
10.20944/preprints202503.0542.v1
Open publication

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Cullin-RING Ubiquitin Ligases in Neurodevelopment and Neurodevelopmental DisordersDOI 10.20944/preprints202503.0542.v1
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