Article
The ataxia (axJ) mutation causes abnormal GABAA receptor turnover in mice.
PLoS genetics - 1 Sept 2009
Lappe-Siefke Corinna, Loebrich Sven, Hevers Wulf, Waidmann Oliver B, Schweizer Michaela, Fehr Susanne, Fritschy Jean-Marc, Dikic Ivan, Eilers Jens, Wilson Scott M, Kneussel Matthias
Abstract excerpt
Ataxia represents a pathological coordination failure that often involves functional disturbances in cerebellar circuits. Purkinje cells (PCs) characterize the only output neurons of the cerebellar cortex and critically participate in regulating motor coordination. Although different genetic mutations are known that cause ataxia, little is known about the underlying cellular mechanisms. Here we show that a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.