Article

DNA clamp function of the mono-ubiquitinated Fanconi Anemia FANCI-FANCD2 complex

2019-11-25

Abstract excerpt

<h4>ABSTRACT</h4> The FANCI-FANCD2 (ID) complex, mutated in the Fanconi Anemia (FA) cancer predisposition syndrome, is required for the repair of replication forks stalled at DNA interstrand crosslinks (ICL) and related lesions 1 . The FA pathway is activated when two replication forks converge onto an ICL 2 , triggering the mono-ubiquitination of the ID complex. ID mono-ubiquitination is essential for ICL repa...

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Literature Corpus work: 8200a7d4-7836-549d-9a69-ddacd17394f5
DOI: 10.1101/854133

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