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Article

Structural insights into 5' flap DNA unwinding and incision by the human FAN1 dimer.

Nature communications - 11 Dec 2014

Zhao Qi, Xue Xiaoyu, Longerich Simonne, Sung Patrick, Xiong Yong

Abstract excerpt

Human FANCD2-associated nuclease 1 (FAN1) is a DNA structure-specific nuclease involved in the processing of DNA interstrand crosslinks (ICLs). FAN1 maintains genomic stability and prevents tissue decline in multiple organs, yet it confers ICL-induced anti-cancer drug resistance in several cancer subtypes. Here we report three crystal structures of human FAN1 in complex with a 5' flap DNA substrate, showing that...

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Share to Crystallography, X-Ray
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25500724
DOI: 10.1038/ncomms6726
PMCID: PMC4268874

Genes

FAN1
FANCD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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