Article

FANCD2-FANCI is a clamp stabilized on DNA by monoubiquitination during DNA repair

2019-11-28

Abstract excerpt

Vertebrate DNA crosslink repair is a crucial process that excises toxic replication-blocking DNA interstrand crosslinks 1 . This pathway fails in the inherited human disease Fanconi anemia (FA), resulting in abnormal development, loss of blood production, and marked cancer susceptibility 2 . Numerous factors involved in crosslink repair have been identified, and mutations in their corresponding genes cause FA 3...

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Literature Corpus work: 71d99321-d0a7-525f-8387-e10f42ab7a92
DOI: 10.1101/858225

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