Article

Brain defence by the extracellular matrix protein Cochlin

2025-11-06

Abstract excerpt

The vertebrate brain is protected from infection by tight barriers. However, several barrier structures, including circumventricular organs, can be breached by pathogens. Here, we show that Cochlin, an extracellular matrix-binding protein with anti-bacterial properties, is produced in barrier structures and contributes to immune defence. Transcriptome analysis and in situ hybridisation indicate that cochlin is e...

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Literature Corpus work: 81ff6a04-9dec-59c2-97dd-c6316d1a8794
DOI: 10.1101/2025.11.05.686104

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