Article
Periphilin is strongly expressed in the murine nervous system and is indispensable for murine development.
Genesis (New York, N.Y. : 2000) - 1 Oct 2009
Soehn Anne S, Pham Thu-Trang, Schaeferhoff Karin, Floss Thomas, Weisenhorn Daniela M Vogt, Wurst Wolfgang, Bonin Michael, Riess Olaf
Abstract excerpt
Periphilin is involved in multiple processes in vivo. To explore its physiological role from an organismic perspective, we generated mice with a gene trap insertion in the periphilin-1 gene. Based on beta-gal reporter activity, a widespread periphilin expression was evident, especially in the developing somites and limbs, the embryonic nervous system, and the adult brain. In accordance with this broad expression,...
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