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Bacterial induction of Snail1 contributes to blood-brain barrier disruption

10 May 2015

Abstract excerpt

Bacterial meningitis is a serious infection of the CNS that results when blood-borne bacteria are able to cross the blood-brain barrier (BBB). Group B Streptococcus (GBS) is the leading cause of neonatal meningitis; however, the molecular mechanisms that regulate bacterial BBB disruption and penetration are not well understood. Here, we found that infection of human brain microvascular endothelial cells (hBMECs)...

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PMID: 25961453
DOI: 10.1172/jci74159

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