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Cellular mechanisms of microbial proteins contributing to invasion of the blood-brain barrier. MicroReview

1 May 2001

Abstract excerpt

One of the least understood issues in the pathogenesis and pathophysiology of microbial infection of the central nervous system (CNS) is how microorganisms cross the blood-brain barrier (BBB), which separates brain interstitial space from blood and is formed by the tight junctions of brain microvascular endothelial cells (BMEC). BMEC monolayer and bilayer culture systems have been developed as in vitro models to...

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PMID: 11298651
DOI: 10.1046/j.1462-5822.2001.00116.x

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