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An original infection model identifies host lipoprotein import as a route for blood-brain barrier crossing

30 Nov 2020

Abstract excerpt

Pathogens able to cross the blood-brain barrier (BBB) induce long-term neurological sequelae and death. Understanding how neurotropic pathogens bypass this strong physiological barrier is a prerequisite to devise therapeutic strategies. Here we propose an innovative model of infection in the developing Drosophila brain, combining whole brain explants with in vivo systemic infection. We find that several mammalian...

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PMID: 33257684
DOI: 10.1038/s41467-020-19826-2

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