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Cryptococcal dissemination to the central nervous system requires the vacuolar calcium transporter Pmc1

7 Nov 2017

Abstract excerpt

Cryptococcus neoformans is a basidiomycetous yeast and the cause of cryptococcosis in immunocompromised individuals. The most severe form of the disease is meningoencephalitis, which is one of the leading causes of death in HIV/AIDS patients. In order to access the central nervous system, C. neoformans relies on the activity of certain virulence factors such as urease, which allows transmigration through the...

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PMID: 29113016
DOI: 10.1111/cmi.12803

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