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Article

Meningococcal Type IV Pili Recruit the Polarity Complex to Cross the Brain Endothelium

11 Jun 2009

Abstract excerpt

Breaking the Barrier Being able to deliver drugs into the brain to treat degenerative diseases such as Alzheimer's or Parkinson's requires the ability to traverse the blood-brain barrier (BBB). Understanding the formation of the very specific adherent junctions (AJ) and tight junctions present at the BBB cell junctions is a prerequisite to the design of such therapeutics. However, diminishing the expression of...

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PMID: 19520910
DOI: 10.1126/science.1173196

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