Article

An original model of brain infection identifies the hijacking of host lipoprotein import as a bacterial strategy for blood-brain barrier crossing

2020-02-28

Abstract excerpt

Pathogens able to cross the blood-brain barrier (BBB) induce long-term neurological sequelae and death. Understanding how neurotropic pathogens bypass this strong physiological barrier is a prerequisite to devise therapeutic strategies. Here we propose an innovative model of infection in the developing Drosophila brain, combining whole brain explants with in vivo systemic infection. We identified several mammalia...

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Identifiers and source

Literature Corpus work: be15957f-f8cc-5c06-8784-024a0a30dab7
DOI: 10.1101/2020.02.28.970376

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