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High-resolution cryo-electron microscopy of the human CDK-activating kinase for structure-based drug design

2023-04-07

Abstract excerpt

Rational design of next-generation therapeutics can be facilitated by high-resolution structures of drug targets bound to small-molecule inhibitors. However, application of structure-based methods to macromolecules refractory to crystallisation has been hampered by the often-limiting resolution and throughput of cryogenic electron microscopy (cryo-EM). Here, we use high-resolution cryo-EM to determine structures o...

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Literature Corpus work
81f21e75-2e29-501d-9134-a27b906b26e9
DOI
10.1101/2023.04.07.536029
Open publication

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High-resolution cryo-electron microscopy of the human CDK-activating kinase for structure-based drug designDOI 10.1101/2023.04.07.536029
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