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Cyclin-Dependent Kinases: Bridging Their Structure and Function Through Computations

1 Sept 2011

Abstract excerpt

Cyclin-dependent kinases (CDKs) are one of the most promising target families for drug discovery for several diseases, such as cancer and neurodegenerative disorders. Over the years, structural insights on CDKs have demonstrated high protein plasticity, with several cases where two or more structures of the same protein adopt different conformations. This has generated a great deal of interest in understanding...

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PMID: 21882947
DOI: 10.4155/fmc.11.113

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