Article
Increased habenular connectivity in opioid users is associated with an α5 subunit nicotinic receptor genetic variant.
The American journal on addictions - 1 Oct 2017
Curtis Kaylah, Viswanath Humsini, Velasquez Kenia M, Molfese David L, Harding Mark J, Aramayo Eduardo, Baldwin Philip R, Ambrosi Elisa, Madan Alok, Patriquin Michelle, Frueh B Christopher, Fowler J Christopher, Kosten Thomas R, Nielsen David A, Salas Ramiro
Abstract excerpt
BACKGROUND AND OBJECTIVES: Opioid use disorder (OUD) is a chronic disorder with relapse based on both desire for reinforcement (craving) and avoidance of withdrawal. The aversive aspect of dependence and relapse has been associated with a small brain structure called the habenula, which expresses large numbers of both opioid and nicotinic receptors. Additionally, opioid withdrawal symptoms can be induced in...
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