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Article

Quinolinate salvage and insights for targeting NAD biosynthesis in group A streptococci.

Journal of bacteriology - 1 Feb 2013

Sorci Leonardo, Blaby Ian K, Rodionova Irina A, De Ingeniis Jessica, Tkachenko Sergey, de Crécy-Lagard Valérie, Osterman Andrei L

Abstract excerpt

The essential coenzyme NAD plays important roles in metabolic reactions and cell regulation in all organisms. As such, NAD synthesis has been investigated as a source for novel antibacterial targets. Cross-species genomics-based reconstructions of NAD metabolism in group A streptococci (GAS), combined with focused experimental testing in Streptococcus pyogenes, led to a better understanding of NAD metabolism in...

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Identifiers

PMID: 23204464
DOI: 10.1128/JB.02002-12
PMCID: PMC3562111

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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